Autophagy and Transporter-Based Multi-Drug Resistance
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چکیده
منابع مشابه
Autophagy and Transporter-Based Multi-Drug Resistance
All the therapeutic strategies for treating cancers aim at killing the cancer cells via apoptosis (programmed cell death type I). Defective apoptosis endow tumor cells with survival. The cell can respond to such defects with autophagy. Autophagy is a cellular process by which cytoplasmic material is either degraded to maintain homeostasis or recycled for energy and nutrients in starvation. A pl...
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Human chromosome 11p15.5 and distal mouse chromosome 7 include a megabase-scale chromosomal domain with multiple genes subject to parental imprinting. Here we describe mouse and human versions of a novel imprinted gene, IMPT1 , which lies between IPL and p57 KIP2 and which encodes a predicted multi-membrane-spanning protein similar to bacterial and eukaryotic polyspecific metabolite transporter...
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The majority of chemo/radiotherapies inhibit cancer cell growth by activating cell death pathways, such as apoptosis, necrosis, and autophagy-associated cell death. However, as the disease progresses, cancer cells can acquire a variety of genetic and epigenetic alterations, which leads to dysregulation of cell death-associated signaling pathways and chemo/radioresistance. Designing novel drugs ...
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The ultimate cause of treatment failure for many forms of malignant and infectious diseases is the development of resistance to a broad range of cytotoxic drugs. Hence, despite significant advances in cancer treatment, multidrug resistance (MDR) remains a major clinical problem and leads to limited therapeutic options and poor patient outcome in a number of cancers, including high-risk neurobla...
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Pseudomonas aeruginosa is among the most important pathogens in the nosocomial infections. A genetic mobile element, the integron, is one of the major agents involved in dissemination of multi-drug resistance among gram negative bacteria. During a descriptive study from October 2009 to August 2010, some 130 P. aeruginosa clinical isolates were collected from different wards of three hospitals...
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ژورنال
عنوان ژورنال: Cells
سال: 2012
ISSN: 2073-4409
DOI: 10.3390/cells1030558